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Guter Umgang mit HIlfsstoffen in der Tablettierung<\/span> <\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":" Guter Umgang mit HIlfsstoffen in der Tablettierung\ud83d\udc49 Bedeutung \u00fcber das Verformungsverhalten hinaus Sowohl bei der Verwendung von Schmierstoffen zur Tablettierung in der Produktion als auch in der Entwicklung ist es wichtig, mehr als nur das Verformungsverhalten der Rezeptur zu ber\u00fccksichtigen.\ud83d\udc49 Die goldene Regel f\u00fcr HilfsstoffeF\u00fcr alle HIlfsstoffe gilt die goldene Regel: so viel wie […]<\/p>","protected":false},"author":8,"featured_media":6079,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[27],"tags":[38,82,318,45,44],"class_list":["post-6073","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glossar","tag-arzneimittelentwicklung","tag-pharmaceutical-production","tag-schmierstoffe","tag-solids","tag-solidsdevelopment"],"yoast_head":"\n
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<\/span>\ud83d\udc49 Importance beyond deformation behaviour<\/span> <\/span>
<\/span>When using lubricants for tableting in both production and development, it is important to consider more than just the deformation behaviour of the formulation.<\/span>
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<\/span>\ud83d\udc49 Die goldene Regel f\u00fcr Hilfsstoffe<\/span><\/span>
<\/span>F\u00fcr alle HIlfsstoffe gilt die goldene Regel: so viel wie n\u00f6tig, aber so wenig wie m\u00f6glich. Denn Hilfsstoffe verringern nicht nur die Tablettenfestigkeit, sondern k\u00f6nnen sich auch negativ auf die Aufl\u00f6sungsrate des Wirkstoffs auswirken. Der Grund daf\u00fcr ist, dass sie meist hydrophob sind und daher verhindern, dass das Wasser den API aufl\u00f6st.<\/span>
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<\/span>\ud83d\udc49 The crucial role of distribution<\/span> <\/span>
<\/span>Additionally, the distribution of the lubricant within the formulation is crucial. In contrast to the API and all other excipients, where an attempt is made to achieve the best possible and most even distribution within the tableting batch, the lubricant should not be distributed as well as possible. Longer mixing times and higher mixing intensities result in so-called overlubrication where the lubricant in distributed that good, that the bonding capacity within the formulation is reduced tremendously and the tablet strength can drop to zero.<\/span>
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<\/span>\ud83d\udc49 HIlfsstoffe sind obligatorisch, m\u00fcssen aber gehandhabt werden<\/span>
<\/span>Nevertheless, lubricants are mandatory in most formulations to prevent tablet damage due to sticking. And in some cases, they can even help to improve the flowability a bit, because the powder particles can glide better.<\/span><\/p>\n