[et_pb_section fb_built=“1″ _builder_version=“4.21.0″ _module_preset=“default“ min_height=“128px“ custom_margin=“-1px|||||“ custom_padding=“56px|||||“ global_colors_info=“{}“][et_pb_row _builder_version=“4.21.0″ _module_preset=“default“ custom_padding=“0px|||||“ global_colors_info=“{}“][et_pb_column type=“4_4″ _builder_version=“4.21.0″ _module_preset=“default“ global_colors_info=“{}“][et_pb_text _builder_version=“4.21.0″ _module_preset=“default“ custom_margin=“-51px|||||“ global_colors_info=“{}“]<\/p>\n
Wetting Agents: How They Improve the Dissolution Rate of APIs<\/strong><\/p>\n Wetting agents are surface-active substances which reduce the surface tension of water. By improving the wettability of hydrophobic substances, they increase the dissolution rate of APIs.<\/p>\n \ud83d\udc49 Liquid and Paste-Like Wetting Agents in Wet Granulation<\/strong><\/p>\n A lot of these standard surface-active substances are liquid or have a paste-like consistency and can therefore only be processed during wet granulation. A careful application of the surface-active substances is necessary to avoid foaming when spraying the granulation liquid.<\/p>\n \ud83d\udc49 Solid Wetting Agents in Dry Granulation<\/strong><\/p>\n If no wet granulation is used as manufacturing method, the surface-active substances need to be solid so that they can be mixed directly to the dry granulation or direct compaction blend.<\/p>\n \ud83d\udc49 Examples of Common Solid Wetting Agents<\/strong><\/p>\n Typical representatives are: <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":" Benetzungsmittel: Wie sie die Aufl\u00f6sungsrate von Wirkstoffen verbessern \u2b05\ufe0f Benetzungsmittel sind oberfl\u00e4chenaktive Substanzen, die die Oberfl\u00e4chenspannung von Wasser reduzieren. Durch die verbesserte Benetzbarkeit hydrophober Substanzen erh\u00f6hen sie die Aufl\u00f6sungsrate von Wirkstoffen. \ud83d\udc49 Fl\u00fcssige und pastenartige Benetzungsmittel in der Feuchtgranulation Viele dieser standardm\u00e4\u00dfigen oberfl\u00e4chenaktiven Substanzen sind fl\u00fcssig oder haben eine pastenartige Konsistenz und k\u00f6nnen daher nur […]<\/p>","protected":false},"author":8,"featured_media":6140,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[27],"tags":[38,43,82,45,44,358],"class_list":["post-6135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glossar","tag-arzneimittelentwicklung","tag-formulierungsentwicklung","tag-pharmaceutical-production","tag-solids","tag-solidsdevelopment","tag-wetting-agents"],"yoast_head":"\n
\u25aa\ufe0f Sodium Dodecyl Sulphate (SDS)
\u25aa\ufe0f Poloxamer
\u25aa\ufe0f Sodiumdoccusate<\/p>\n