Lamination in Tablets: A Dive into a Common Tablet Defect
In any production process, errors can occur. Speaking about pharmaceutical tablet production one of these defects is known as lamination.
But what exactly is lamination, and how can it be prevented? In this article, we’ll summarize a few key points.
What is Lamination?
Lamination occurs when a tablet horizontally separates into one or more layers parallel to the surface. Imagine having a sandwich, and suddenly, the individual layers start to separate from each other. That’s precisely what happens during tablet lamination.
Why Does Lamination Occur?
There are several reasons for lamination – here are a few examples:
– Entrapped Air: Air trapped during the compression process can exert pressure within the tablet.
– Inadequate Granulation: Improperly prepared granules with a high fines content can compromise binding.
– Inproper moisture content: powder blends and granules that are too dry may tend to laminate
How Can Lamination Be Prevented?
Lamination can be prevented as far as possible if the right aspects are considered. Proven strategies include:
– Granulation Process Optimization: Well-prepared granules with a low number of fines
– Adjustment of Compression Pressure: Pre-Compaction can significantly reduce the lamination tendency! Checking for the right (pre) pressure level makes all the difference.
– Air Venting: Allow the air to escape. This can be realized by slowing down the turret speed.
With our experience and the right strategies, lamination can be effectively prevented. We constantly put our knowledge base to the test in order to optimize your formulations and make them more robust.